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Sunday, May 25, 2014

artemesia annua l.,huaya,chaya

hello m . everything fine ?From the point off view off herbal medicine i recapitulate¨, the wormwood extract from artemisia annua l was originally used as an infusion for the treatment off malaria , after the archeologicial recovery off the recipe in china it became used and produced in africa and asia from the seventies on,. alcoholic solutions -tincture- give a higher compound concentration, the tablets used on the base off the dry extract in some cases suggests allergic deadly reactions in tanzania one text mentioned-as a cancer treatment for breastcancer it can be very effective with the extracted component artemisinin in watery solution and pumping up the iron content off cancer cells at the same time with holotransferrin, in herbal medicin context , there has to be looked to natural ways to enhance the iron content off cancer cells , which naturally is higher than healthy cells, and so the artemisinin does its work very efficient, that artemisinin part could be done with the infusion or an alcoholic tincture from the point off view off natural medicin, for the pumping up off the iron content off cancer cells a remedy can posibly be found....it just needs some more random literature research at its best, the dried extract is very high in concentration so the tincture or the infusion could sail around most alergic reactions i guess....so far so good...wish you all the best

,wormwood originally used to combat malaria, the recipe was undigged in an archeological dig in the 70ties



This is an archived article.

November 26, 2001



Ancient Chinese folk remedy may hold key to non-toxic cancer treatment

Rob Harrill



Posted under: Archive





Two bioengineering researchers at the University of Washington have discovered a promising potential treatment for cancer among the ancient arts of Chinese folk medicine.



Research Professor Henry Lai and assistant research Professor Narendra Singh have exploited the chemical properties of a wormwood derivative to target breast cancer cells, with surprisingly effective results. A study in the latest issue of the journal Life Sciences describes how the derivative killed virtually all human breast cancer cells exposed to it within 16 hours.



“Not only does it appear to be effective, but it’s very selective,” Lai said. “It’s highly toxic to the cancer cells, but has a marginal impact on normal breast cells.”



The compound, artemisinin, isn’t new. It apparently was extracted from the plant Artemesia annua L., commonly known as wormwood, thousands of years ago by the Chinese, who used it to combat malaria. However, the treatment was lost over time. Artemisinin was rediscovered during an archaeological dig in the 1970s that unearthed recipes for ancient medical remedies, and has become widely used in modern Asia and Africa to fight the mosquito-borne disease.



The compound helps control malaria because it reacts with the high iron concentrations found in the malaria parasite. When artemisinin comes into contact with iron, a chemical reaction ensues, spawning charged atoms that chemists call “free radicals.” The free radicals attack cell membranes, breaking them apart and killing the single-cell parasite.



About seven years ago, Lai began to hypothesize that the process might work with cancer, too.



“Cancer cells need a lot of iron to replicate DNA when they divide,” Lai explained. “As a result, cancer cells have much higher iron concentrations than normal cells. When we began to understand how artemisinin worked, I started wondering if we could use that knowledge to target cancer cells.”



Lai devised a potential method and began to look for funding, obtaining a grant from the Breast Cancer Fund in San Francisco. Meanwhile, the UW patented his idea.



The thrust of the idea, according to Lai and Singh, was to pump up the cancer cells with maximum iron concentrations, then introduce artemisinin to selectively kill the cancer. To accommodate a rate of iron intake greater than normal cells, cancer cell surfaces feature greater concentrations of transferrin receptors — cellular pathways that allow iron into a cell. Breast cancer cells are no exception. They have five to 15 times more transferrin receptors on their surface than normal breast cells.



In the current study, the researchers subjected sets of breast cancer cells and normal breast cells to doses of holotransferrin (which binds with transferrin receptors to transport iron into cells), dihydroartemisinin (a more water-soluble form of artemisinin) and a combination of both compounds. Cells exposed to just one of the compounds showed no appreciable effect. Normal breast cells, exposed to both compounds, exhibited a minimal effect. But the response by cancer cells when hit with first holotransferrin, then dihydroartemisinin, was dramatic.



After eight hours, just 25 percent of the cancer cells remained. By the time 16 hours had passed, nearly all the cells were dead.



An earlier study involving leukemia cells yielded even more impressive results. Those cells were eliminated within eight hours. A possible explanation might be the level of iron in the leukemia cells.



“They have one of the highest iron concentrations among cancer cells,” Lai explained. “Leukemia cells can have more than 1,000 times the concentration of iron that normal cells have.”



The next step, according to Lai, is animal testing. Limited tests have been done in that area. In an earlier study, a dog with bone cancer so severe it couldn’t walk made a complete recovery in five days after receiving the treatment. But more rigorous testing is needed.



If the process lives up to its early promise, it could revolutionize the way some cancers are approached, Lai said. The goal would be a treatment that could be taken orally, on an outpatient basis.



“That would be very easy, and this could make that possible,” Lai said. “The cost is another plus — at $2 a dose, it’s very cheap. And, with the millions of people who have already taken artemisinin for malaria, we have a track record showing that it’s safe.”



Whatever happens, Lai said, a portion of the credit will have to go to unknown medical practitioners, long gone now.



“The fascinating thing is that this was something the Chinese used thousands of years ago,” he said. “We simply found a different application.”



###



For more information, contact Lai at (206) 543-1071 or http://www.elsevier.com/locate/lifescie







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Related StoriesAncient Chinese remedy shows potential in preventing breast cancer December 19, 2005

UW licenses potential cancer treatment derived from ancient Chinese folk remedy October 14, 2004

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Ancient Chinese remedy proves effective against cancer cells November 29, 2001

 http://www.washington.edu/news/2001/11/26/ancient-chinese-folk-remedy-may-hold-key-to-non-toxic-cancer-treatment/



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